肿瘤血管生成的动态对比增强超声成像的最新进展。
Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis.
作者信息
Saini Reshu, Hoyt Kenneth
机构信息
Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA ; Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA ; Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA ; Electrical & Computer Engineering, University of Alabama at Birmingham, Birmingham, AL, USA ; Comprehensive Cancer Center, University of Alabama at Birmingham, Volker Hall G082, 1670 University Boulevard, Birmingham, AL 35294, USA.
出版信息
Imaging Med. 2014 Feb 1;6(1):41-52. doi: 10.2217/iim.13.74.
Angiogenesis is a critical process for tumor growth and metastatic dissemination. There is tremendous interest in the development of noninvasive methods for imaging tumor angiogenesis, and ultrasound (US) is an emerging platform technology to address this challenge. The introduction of intravascular microbubble contrast agents not only allows real-time visualization of tumor perfusion during an US examination, but they can be functionalized with specific ligands to permit molecular US imaging of angiogenic biomarkers that are overexpressed on the tumor endothelium. In this article, we will review current concepts and developing trends for US imaging of tumor angiogenesis, including relevant preclinical and clinicsal findings.
血管生成是肿瘤生长和转移扩散的关键过程。人们对开发用于肿瘤血管生成成像的非侵入性方法有着浓厚兴趣，而超声（US）是应对这一挑战的新兴平台技术。血管内微泡造影剂的引入不仅能在超声检查期间实现肿瘤灌注的实时可视化，还可通过特定配体进行功能化，以实现对肿瘤内皮细胞上过度表达的血管生成生物标志物的分子超声成像。在本文中，我们将综述肿瘤血管生成超声成像的当前概念和发展趋势，包括相关的临床前和临床研究结果。
Zotero 插件