由β-叠氮基二硫化物与羧酸或酸酐简洁合成2,4-二取代噻唑：胱硫噻唑C的不对称合成
Concise synthesis of 2,4-disubstituted thiazoles from β-azido disulfides and carboxylic acids or anhydrides: asymmetric synthesis of cystothiazole C.
作者信息
Liu Yi, Sun Xue, Zhang Xing, Liu Jun, Du Yuguo
机构信息
State Key Laboratory of Environmental Chemistry and Eco-toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
出版信息
Org Biomol Chem. 2014 Nov 14;12(42):8453-61. doi: 10.1039/c4ob01460j.
PMID:25223403
Abstract
A novel and efficient method for the one-pot synthesis of 2,4-disubstituted thiazoles from carboxylic acids or anhydrides is presented. Based on this new method, the total synthesis of the bis-2,4-disubstituted bis(thiazoles) natural product cystothiazole C is also presented.
摘要
本文提出了一种新颖且高效的从羧酸或酸酐一锅法合成2,4-二取代噻唑的方法。基于此新方法，还介绍了双-2,4-二取代双（噻唑）天然产物胱硫噻唑C的全合成。
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