通过二芳基碘鎓盐与腈的串联环化反应合成菲啶衍生物。

Synthesis of phenanthridine derivatives via cascade annulation of diaryliodonium salts and nitriles.

作者信息

Li Jian, Wang Hongni, Sun Jiangtao, Yang Yang, Liu Li

机构信息

School of Pharmaceutical Engineering & Life Sciences, Chang Zhou University, Changzhou, 213164, P. R. China.

出版信息

Org Biomol Chem. 2014 Oct 28;12(40):7904-8. doi: 10.1039/c4ob01504e.

DOI:10.1039/c4ob01504e

PMID:25223479

Abstract

A cascade coupling reaction toward a variety of phenanthridine derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction of diaryliodonium salts and nitriles, and undergoes cyclization into the phenanthridine core.

摘要

已经开发出一种用于合成多种菲啶衍生物的串联偶联反应。这种串联转化过程是通过铜催化的二芳基碘鎓盐与腈的偶联反应进行的，并经历环化反应形成菲啶核心结构。