氯化铁促进芳基异腈与甲酰胺进行羧酰胺化反应及环化反应生成菲啶-6-羧酰胺。
FeCl3-promoted carboxamidation and cyclization of aryl isonitriles with formamides toward phenanthridine-6-carboxamides.
作者信息
Tu Hai-Yong, Liu Yu-Rong, Chu Jing-Jing, Hu Bo-Lun, Zhang Xing-Guo
机构信息
College of Chemistry and Materials Engineering, Wenzhou University , Wenzhou 325035, China.
出版信息
J Org Chem. 2014 Oct 17;79(20):9907-12. doi: 10.1021/jo502022c. Epub 2014 Sep 30.
PMID:25244055
Abstract
An iron-promoted tandem carboxamidation and cyclization between aryl isonitriles and formamides has been developed. The one-pot strategy can be applied to a wide range of 2-isocyanobiphenyls and formamides with excellent functional group tolerance for the synthesis of phenanthridine-6-carboxamides in moderate to excellent yields.
摘要
已开发出一种铁促进的芳基异腈与甲酰胺之间的串联羧酰胺化和环化反应。这种一锅法策略可应用于多种2-异氰基联苯和甲酰胺，对官能团具有出色的耐受性，能够以中等至优异的产率合成菲啶-6-羧酰胺。
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