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一种针对c-Met的DNA适配体可抑制癌细胞迁移。

A DNA aptamer to c-Met inhibits cancer cell migration.

作者信息

Ueki R, Sando S

机构信息

INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.

出版信息

Chem Commun (Camb). 2014 Nov 7;50(86):13131-4. doi: 10.1039/c4cc06016d.

DOI:10.1039/c4cc06016d
PMID:25223895
Abstract

The HGF/c-Met pathway is known to play a key role in cancer metastasis. CLN0003_SL1, a 50-mer DNA aptamer that binds to the c-Met protein, was found to inhibit HGF-induced c-Met activation. This aptamer could suppress cancer cell motility in vitro.

摘要

已知HGF/c-Met信号通路在癌症转移中起关键作用。CLN0003_SL1是一种与c-Met蛋白结合的50聚体DNA适配体，被发现可抑制HGF诱导的c-Met激活。这种适配体在体外可抑制癌细胞的运动性。

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[3]
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[9]
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[10]
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