早期和晚期海胆组蛋白H4信使核糖核酸对DNA合成抑制剂的反应不同。

The early and late sea urchin histone H4 mRNAs respond differently to inhibitors of DNA synthesis.

作者信息

Jarvis J W, Marzluff W F

机构信息

Department of Chemistry, Florida State University, Tallahassee 32306.

出版信息

Dev Biol. 1989 Apr;132(2):325-30. doi: 10.1016/0012-1606(89)90229-7.

DOI:10.1016/0012-1606(89)90229-7

PMID:2522406

Abstract

The effect of inhibiting DNA synthesis on the concentration of the alpha-histone mRNA and the late histone mRNAs in sea urchin embryos was measured. The alpha-histone mRNA concentrations did not change, while the late histone mRNA concentrations were rapidly reduced at the three developmental stages (morula, blastula, and mesenchyme blastula) tested. The rapid degradation of the late histone mRNAs was prevented when protein synthesis was inhibited.

摘要

测定了抑制DNA合成对海胆胚胎中α-组蛋白mRNA和晚期组蛋白mRNA浓度的影响。α-组蛋白mRNA浓度没有变化，而在测试的三个发育阶段（桑椹胚、囊胚和间充质囊胚），晚期组蛋白mRNA浓度迅速降低。当蛋白质合成受到抑制时，晚期组蛋白mRNA的快速降解被阻止。