Gupta Sumit, Sutradhar Rinku, Guttmann Astrid, Sung Lillian, Pole Jason D
Division of Haematology/Oncology, Department of Paediatrics and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, 555 University Avenue, Toronto, Canada M5G 1X8.
Institute for Clinical Evaluative Sciences, G1 06, 2075 Bayview Avenue, Toronto, Canada M4N 3M5; Dalla Lana School of Public Health, University of Toronto, 6th floor, 155 College Street, Toronto, Canada M5T 3M7.
Leuk Res. 2014 Dec;38(12):1407-12. doi: 10.1016/j.leukres.2014.08.017. Epub 2014 Sep 1.
The impact of socioeconomic status (SES) upon childhood cancer outcomes has not been extensively examined. Our objective was to determine the association between SES and event-free survival (EFS) among children with acute lymphoblastic leukemia (ALL) diagnosed in Ontario, Canada from 1995-2011 (N=1541) using Cox proportional hazards. Neither neighborhood-level median income quintile, distance from tertiary center, or rural residence significantly predicted EFS in the context of a universal healthcare system. Immigrant children experienced significantly superior EFS; confounding by ethnicity could not be ruled out. Confirmatory studies using additional individual-level SES variables are warranted.
社会经济地位（SES）对儿童癌症治疗结果的影响尚未得到广泛研究。我们的目标是利用Cox比例风险模型，确定1995年至2011年在加拿大安大略省诊断出的急性淋巴细胞白血病（ALL）患儿（N = 1541）的SES与无事件生存期（EFS）之间的关联。在全民医疗保健系统的背景下，邻里层面的收入中位数五分位数、与三级医疗中心的距离或农村居住情况均未显著预测EFS。移民儿童的EFS显著更好；无法排除种族因素的混杂影响。有必要使用更多个体层面的SES变量进行验证性研究。
