Lim Alvin, Krajina Katarina, Marsland Anna L
Department of Psychology, University of Pittsburgh, Pittsburgh, Pa., USA.
Mod Trends Pharmacopsychiatry. 2013;28:175-87. doi: 10.1159/000346362. Epub 2013 Feb 27.
Evidence suggests that inflammation, an innate immune response facilitating recovery from injury and pathogenic invasion, is positively associated with age-related cognitive decline and may play a role in risk for dementia. Physiological pathways linking the peripheral immune and central nervous systems are outlined, and studies linking inflammation with neurocognitive function are overviewed. We also present recent studies from our laboratory showing that midlife inflammation is related to cognitive function and brain morphology. Finally, potential implications for treatment, future directions, and limitations are discussed.
有证据表明，炎症作为一种有助于从损伤和病原体入侵中恢复的先天性免疫反应，与年龄相关的认知衰退呈正相关，并且可能在痴呆症风险中起作用。概述了连接外周免疫系统和中枢神经系统的生理途径，并综述了将炎症与神经认知功能联系起来的研究。我们还展示了来自我们实验室的最新研究，表明中年炎症与认知功能和脑形态有关。最后，讨论了治疗的潜在意义、未来方向和局限性。
