Sabiqa Haider, Post-Graduate, Department of Dermatology, Dow University of Health Sciences, Karachi, Pakistan.
Zarnaz Wahid, Professor & Head of the Department of Dermatology, Dow University of Health Sciences and Civil Hospital, Karachi, Pakistan.
Pak J Med Sci. 2014 Sep;30(5):1050-3. doi: 10.12669/pjms.305.4451.
To assess the efficacy of Methotrexate in patients with plaque type psoriasis.
This descriptive study was conducted in the department of Dermatology, Civil Hospital Karachi from September 2009 to March 2010. Seventy three patients between 18 to 50 years of age suffering from plaque type psoriasis with PASI score of >10 were included in the study after taking the informed consent. Oral methotrexate in a dose of 7.5 mg/week was given for 8 weeks. The data collected included demographic profile (age and gender), duration of disease, site of involvement, size of plaque, severity of plaque measured by Psoriasis Area and Severity Index (PASI) score before starting the treatment and at the end of treatment. Efficacy was labeled with a PASI score of ≤5 at the end of 8 weeks.
Out of 73 patients there were 45 (61.6%) males and 28 (38.4%) females. The mean ±SD age was 40.0±12.6 years. The mean baseline PASI score showed clear and comparable improvement from a mean ± SD PASI score of 14.8±4.2 to 4.9±4.3.Twenty nine (40%) patients had an almost complete remission during the 8 weeks of treatment. Partial remission was achieved in 44 (60%) patients. The clearance time for psoriasis ranged from 5-7 weeks (mean 6±0.89 weeks).
Treatment with methotrexate for chronic plaque psoriasis brings satisfactory disease control and improved quality of life.
评估甲氨蝶呤治疗斑块状银屑病患者的疗效。
这是一项描述性研究，于 2009 年 9 月至 2010 年 3 月在卡拉奇民事医院皮肤科进行。在获得知情同意后，纳入了年龄在 18 至 50 岁之间、患有斑块状银屑病且 PASI 评分＞10 的 73 例患者。给予口服甲氨蝶呤 7.5mg/周，治疗 8 周。收集的数据包括人口统计学特征（年龄和性别）、疾病持续时间、受累部位、斑块大小、治疗前和治疗结束时用银屑病面积和严重程度指数（PASI）评分测量的斑块严重程度。治疗 8 周后 PASI 评分≤5 为有效。
73 例患者中，男性 45 例（61.6%），女性 28 例（38.4%）。平均年龄±SD 为 40.0±12.6 岁。平均基线 PASI 评分显示出明显且可比的改善，从 14.8±4.2 平均±SD 评分改善至 4.9±4.3。29 例（40%）患者在 8 周治疗期间几乎完全缓解。44 例（60%）患者达到部分缓解。银屑病的清除时间为 5-7 周（平均 6±0.89 周）。
甲氨蝶呤治疗慢性斑块状银屑病可有效控制疾病，提高生活质量。
