Sarnoff Deborah S, Gotkin Robert H
J Drugs Dermatol. 2014 Sep;13(9):1038-46.
Cervicofacial aging is often characterized by a combination of skin and subcutaneous tissue laxity, midfacial deflation, an accumulation of excess submental fat, an obtuse cervicomental angle, jowls, and rhytides of the face and neck. Traditional treatment, and the "gold standard" against which other treatments are compared, is a facelift.
To demonstrate that a combination technique called ACELIFT - an acronym for the Augmentation of Collagen and Elastin using Lasers, Injectable neurotoxins, Fillers, and Topicals - in selected patients, is a viable, safe, and effective alternative to a facelift.
Ten healthy women, ages 50 to 62 (mean age = 58), with cervical and facial stigmata of aging were enrolled in a prospective study conducted in the authors' private practice. Patients underwent a two-step procedure; the first step was laser lipolysis of the submental and anterior cervical areas with a pulsed 1440 nm Nd:YAG laser with a side-firing fiber (PrecisionTx, Cynosure, Westford, MA). Three months later, the patients were treated in a single session that combined injectable neurotoxin, fillers, and fractional (Fx) CO2 laser resurfacing delivered in a novel "hammock" distribution. After two weeks, following complete re-epithelialization, the patients were started on a topical regimen that included daily use of sunscreen and antioxidants and nightly use of retinoids and peptides. This regimen was continued for a period of six months when all patients returned for final evaluation.
Nine months following the initiation of treatment, all patients were evaluated by the following: Global Aesthetic Improvement Scale, cervicomental angle scale, physician, and subject evaluation. Clinical improvement was evident, and often marked, for all subjects. Both physician and subject satisfaction scores were high, indicating overall satisfaction with the procedure and the outcomes. Side-effects were mild and transient; there were no incidents of adverse scarring, thermal injuries, permanent nerve injury, or dyschromia, hematomas, seromas, or infection. Subjects were likely to recommend the procedure to a friend.
In properly selected patients, the ACELIFT proved to be a safe and effective, minimally invasive alternative to a facelift. There was little downtime and high patient satisfaction.
面颈部老化通常表现为皮肤和皮下组织松弛、中面部凹陷、颏下脂肪堆积、颈颌角钝圆、下颌赘肉以及面部和颈部皱纹等多种情况。传统治疗方法，也是用于与其他治疗方法作比较的“金标准”，是面部提升术。
证明一种名为ACELIFT的联合技术——即使用激光、可注射神经毒素、填充剂和外用药物来增加胶原蛋白和弹性蛋白（Augmentation of Collagen and Elastin using Lasers, Injectable neurotoxins, Fillers, and Topicals的首字母缩写）——在特定患者中是一种可行、安全且有效的面部提升术替代方法。
10名年龄在50至62岁（平均年龄 = 58岁）、存在面颈部老化特征的健康女性参与了在作者私人诊所进行的一项前瞻性研究。患者接受了两步治疗；第一步是使用带有侧射光纤的脉冲1440纳米掺钕钇铝石榴石激光（PrecisionTx，赛诺秀公司，马萨诸塞州韦斯特福德）对颏下和颈前区域进行激光溶脂。三个月后，患者接受单次治疗，该治疗联合了可注射神经毒素、填充剂以及以一种新颖的“吊床”分布方式进行的非剥脱性二氧化碳激光换肤术。两周后，在完全重新上皮化后，患者开始使用一种外用方案，包括每日使用防晒霜和抗氧化剂，以及每晚使用维甲酸和肽。该方案持续六个月，之后所有患者返回进行最终评估。
治疗开始九个月后，通过以下方式对所有患者进行评估：整体美学改善量表、颈颌角量表、医生评估和患者自评。所有受试者都有明显的临床改善，且常常较为显著。医生和患者的满意度评分都很高，表明对该治疗过程和结果总体满意。副作用轻微且短暂；未发生不良瘢痕形成、热损伤、永久性神经损伤或色素沉着异常、血肿、血清肿或感染等情况。受试者很可能会向朋友推荐该治疗方法。
在经过适当挑选的患者中，ACELIFT被证明是一种安全有效的、微创的面部提升术替代方法。恢复时间短，患者满意度高。
