Proebstle Thomas M, Chung Gary, Weissberg Ruth, Pavicic Tatjana
J Drugs Dermatol. 2014 Sep;13(9):1067-72.
A quantitative numerical method for assessing the extent and duration of the inhibitory action of botulinum neurotoxin type A on mimetic muscles would potentially enable more detailed evaluation of the overall efficacy of this aesthetic treatment.
To evaluate skin displacement analysis (SDA) as a tool for assessment of the extent and duration of effect of incobotulinumtoxinA on mimetic muscles in the glabellar region in routine daily practice.
A total dose of 30 U incobotulinumtoxinA was injected into the fronto-glabellar region of 16 subjects. SDA was performed at baseline and during onset and recovery from incobotulinumtoxinA treatment at various timepoints up to 24 weeks after treatment. The reference point for SDA was located at the upper margin of the eyebrow, 30 mm lateral to the median line. To correlate and validate SDA results, semi-quantitative wrinkle score assessments were performed in parallel.
At baseline, the mean horizontal skin displacement was 5.4 mm (standard deviation: ± 1.4 mm). During onset of action after treatment, skin displacement values decreased from baseline (100%) by 46%, 85%, and 90% at day 2, week 1, and week 2, respectively. During recovery from incobotulinumtoxinA action, skin displacement values increased to 33%, 50%, and 93% of the baseline value at 6, 12, and 24 weeks after treatment, respectively. The inhibitory effect of incobotulinumtoxinA was highly variable among subjects, ranging from 25% to 68% of the baseline value 12 weeks after treatment. Overall agreement between SDA values and wrinkle scores was good.
SDA represents a novel, objective method for the quantitative evaluation of the effect of incobotulinumtoxinA on mimetic muscles underlying the fronto-glabellar region, and showed good correlation with wrinkle score assessments. Both SDA and wrinkle score indicated the persistence of treatment effects 24 weeks after injection.
一种用于评估A型肉毒杆菌神经毒素对表情肌抑制作用程度和持续时间的定量数值方法，可能会使对这种美容治疗的整体疗效进行更详细的评估成为可能。
在日常实践中，评估皮肤位移分析（SDA）作为一种工具，用于评估注射用A型肉毒毒素对眉间区域表情肌的作用程度和持续时间。
将总计30 U的注射用A型肉毒毒素注射到16名受试者的额眉间区域。在基线时以及在注射用A型肉毒毒素治疗开始期间和治疗后长达24周的不同时间点恢复过程中进行SDA。SDA的参考点位于眉的上缘，中线外侧30 mm处。为了关联和验证SDA结果，同时进行了半定量皱纹评分评估。
在基线时，平均水平皮肤位移为5.4 mm（标准差：±1.4 mm）。在治疗后的起效期间，皮肤位移值在第2天、第1周和第2周分别从基线（100%）下降了46%、85%和90%。在注射用A型肉毒毒素作用的恢复期间，皮肤位移值在治疗后6周、12周和24周分别增加到基线值的33%、50%和93%。注射用A型肉毒毒素的抑制作用在受试者之间差异很大，治疗后12周为基线值的25%至68%。SDA值与皱纹评分之间的总体一致性良好。
SDA是一种用于定量评估注射用A型肉毒毒素对额眉间区域下方表情肌作用的新颖、客观的方法，并且与皱纹评分评估显示出良好的相关性。SDA和皱纹评分均表明注射后24周治疗效果持续存在。
