Matsuyama T, Tsukamoto N, Kaku T, Matsukuma K, Hirakawa T
Department of Obstetrics and Gynecology, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Acta Cytol. 1989 Mar-Apr;33(2):228-32.
In a 69-year-old woman, a gynecologic smear was the first indication of the presence of a nonepithelial malignant tumor. While first thought to represent an adenocarcinoma, malignant lymphoma was later cytologically suspected because of the presence of isolated large malignant cells with macronucleoli. The initial clinical and histologic studies failed to indicate a malignancy. The malignant cells in postoperative tissue samples showed a positive immunohistochemical reaction for leukocyte-common antigen (LCA) and a negative reaction for epithelial membrane antigen, confirming the cytologic suggestion of a uterine lymphoma. Immunocytochemical staining subsequently performed on the destained cytologic specimen gave a positive immunoreactivity to LCA in the cytoplasm of the malignant cells.
在一名69岁女性中，妇科涂片是发现非上皮性恶性肿瘤的首个迹象。最初认为是腺癌，但后来由于存在带有大核仁的孤立大恶性细胞，细胞学上怀疑为恶性淋巴瘤。最初的临床和组织学研究未能提示恶性肿瘤。术后组织样本中的恶性细胞对白血细胞共同抗原（LCA）免疫组化反应呈阳性，而上皮膜抗原反应呈阴性，证实了子宫淋巴瘤的细胞学推测。随后对脱色的细胞学标本进行免疫细胞化学染色，恶性细胞胞质中LCA免疫反应呈阳性。
