精氨酸加压素及其类似物对豚鼠内耳蜗电位的影响。
The effect of arginine-vasopressin and its analogues upon the endocochlear potential in the guinea pig.
作者信息
Mori N, Shugyo A, Asai H
机构信息
Department of Otolaryngology, Kagawa Medical School, Osaka University Medical School, Japan.
出版信息
Acta Otolaryngol. 1989 Jan-Feb;107(1-2):80-4. doi: 10.3109/00016488909127482.
PMID:2522708
Abstract
The effect of arginine-vasopressin (AVP) and its analogues upon the endocochlear potential (EP) was examined in the guinea pig. AVP decreased the EP reversibly and dose-dependently like lysin-vasopressin (LVP). V1 antagonist failed to block the effect of AVP upon the EP. V2 agonist reversibly decreased the EP like AVP. The results suggest that V2 receptors mediate the action of vasopressin on the EP.
摘要
在豚鼠中研究了精氨酸加压素（AVP）及其类似物对内耳电位（EP）的影响。AVP可使EP像赖氨酸加压素（LVP）一样可逆性降低，且呈剂量依赖性。V1拮抗剂未能阻断AVP对EP的作用。V2激动剂可像AVP一样使EP可逆性降低。结果表明，V2受体介导了加压素对EP的作用。
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