Coldwell D M, Huff J, Marcellus H, Coldwell S G
Department of Radiology, University of Washington, Seattle 98104.
Br J Radiol. 1989 Mar;62(735):234-6. doi: 10.1259/0007-1285-62-735-234.
The use of the nitroimidazole radiation sensitizers, misonidazole and SR-2508, has been limited by a variety of side-effects, principally peripheral neuropathies. In order to increase the effectiveness of radiosensitization and thereby reduce the administered dose of the sensitizers, intra-arterial delivery of SR-2508 was performed and followed with 10 Gy of 4 MeV photon beam radiotherapy in the rabbit V2 carcinoma tumour model. Comparison was made with rabbits treated with an identical dose of SR-2508 given intravenously prior to photon beam radiotherapy. Control animals were treated with radiation therapy only, intra-arterial SR-2508 only, or had no treatment. Neither the radiation therapy alone nor the SR-2508 alone had any effect on tumour growth. In the intra-arterial group, the tumour growth was slower and the size was significantly smaller than all other groups. The results suggest that the intra-arterial infusion of the radiation sensitizer produces greater response of the tumour than intravenous infusion when each is combined with radiation therapy.
硝基咪唑类辐射增敏剂米索硝唑和SR - 2508的应用因多种副作用而受到限制，主要是周围神经病变。为了提高放射增敏效果，从而降低增敏剂的给药剂量，在兔V2癌肿瘤模型中进行了SR - 2508的动脉内给药，随后给予10 Gy的4 MeV光子束放射治疗。并与在光子束放射治疗前静脉给予相同剂量SR - 2508的兔子进行了比较。对照动物仅接受放射治疗、仅接受动脉内SR - 2508或不接受任何治疗。单独的放射治疗和单独的SR - 2508对肿瘤生长均无任何影响。在动脉内给药组中，肿瘤生长较慢，且大小明显小于所有其他组。结果表明，当放射增敏剂与放射治疗联合使用时，动脉内输注比静脉输注能使肿瘤产生更大的反应。
