诺卡菌素ISK-1的杀菌活性：一种替代作用模式
Bactericidal activity of nukacin ISK-1: an alternative mode of action.
作者信息
Roy Urmi, Islam Mohammad Riazul, Nagao Jun-ichi, Iida Hiroshi, Mahin Abdullah-Al, Li Mengqi, Zendo Takeshi, Nakayama Jiro, Sonomoto Kenji
机构信息
a Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture , Graduate School, Kyushu University , Fukuoka , Japan.
出版信息
Biosci Biotechnol Biochem. 2014;78(7):1270-3. doi: 10.1080/09168451.2014.918485. Epub 2014 Jun 18.
We previously reported bacteriostatic action of nukacin ISK-1 against Bacillus subtilis JCM 1465(T). Here, we found its bactericidal activity against Micrococcus luteus DSM 1790 and Staphylococcus simulans 22, showing decrease in cell viability, cell lysis, and dissipation of the membrane potential. Moreover, leakage of small molecules such as K(+), suggested the formation of small-sized or specific K(+)-conducting-pores by nukacin ISK-1.
我们之前报道了诺卡菌素ISK-1对枯草芽孢杆菌JCM 1465(T)的抑菌作用。在此，我们发现它对藤黄微球菌DSM 1790和模仿葡萄球菌22具有杀菌活性，表现为细胞活力下降、细胞裂解以及膜电位消散。此外，K(+)等小分子的泄漏表明诺卡菌素ISK-1形成了小尺寸或特定的K(+)传导孔。
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