Olshan A F, Baird P A, Teschke K
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Am J Hum Genet. 1989 May;44(5):646-51.
An exploratory case-control study of paternal occupation as a risk factor for Down syndrome was conducted. With the use of the British Columbia Health Surveillance Registry, 1,008 cases of live-born Down syndrome were identified for the period 1952-73. Two controls were matched to each case by using the birth files of British Columbia. Paternal occupation was obtained from the birth notice. Elevated maternal age-adjusted relative risks of Down syndrome were found for fathers employed as janitors (odds ratio [OR] = 3.26; 95% confidence interval [C.I.] = 1.02-10.44); mechanics (OR = 3.27; C.I. = 1.57-6.80); farm managers/workers (OR = 2.03; C.I. = 1.25-3.03); material-moving equipment operators (OR = 1.88; C.I. = 0.93-3.82); food processors (OR = 1.79; C.I. = 0.96-3.31); sheet-metal workers, iron workers, and other metalworkers (OR = 1.57; C.I. = 0.92-2.69); and sawmill workers (OR = 1.43; C.I. = 0.90-2.66). This large study provides new leads for further evaluation of the role of paternal exposures in the etiology of Down syndrome.
开展了一项探索性病例对照研究,以调查父亲职业作为唐氏综合征风险因素的情况。利用不列颠哥伦比亚省健康监测登记处的数据,确定了1952年至1973年期间1008例活产唐氏综合征病例。通过使用不列颠哥伦比亚省的出生档案,为每个病例匹配了两名对照。父亲职业信息来自出生通知。研究发现,从事以下职业的父亲,其经产妇年龄调整后的唐氏综合征相对风险升高:门卫(优势比[OR]=3.26;95%置信区间[C.I.]=1.02 - 10.44);机械师(OR = 3.27;C.I. = 1.57 - 6.80);农场经理/工人(OR = 2.03;C.I. = 1.25 - 3.03);物料搬运设备操作员(OR = 1.88;C.I. = 0.93 - 3.82);食品加工人员(OR = 1.79;C.I. = 0.96 - 3.31);钣金工、钢铁工人和其他金属工人(OR = 1.57;C.I. = 0.92 - 2.69);以及锯木厂工人(OR = 1.43;C.I. = 0.90 - 2.66)。这项大型研究为进一步评估父亲接触因素在唐氏综合征病因学中的作用提供了新线索。