来自大鼠肠道黏膜和腹膜肥大细胞的IgE受体表现出肥大细胞亚型特异性差异。

IgE receptors from rat intestinal mucosal and peritoneal mast cells show mast cell subtype-specific differences.

作者信息

Swieter M, Chan B M, Lee T D, Rimmer C J, Froese A, Befus D

机构信息

Immunological Sciences Research Group, University of Calgary, Canada.

出版信息

Int Arch Allergy Appl Immunol. 1989;88(1-2):200-2. doi: 10.1159/000234785.

DOI:10.1159/000234785

PMID:2523356

Abstract

High- (alpha chain) and low-affinity IgE receptors from purified populations of rat intestinal mucosal (IMMC) and peritoneal mast cells (PMC) were characterized by SDS-PAGE. Receptor expression and molecular weight were compared. IMMC yielded 59-kilodalton (kDa) alpha chains of the high-affinity receptors and two forms (58, 50 kDa) of low-affinity receptors, whereas PMC possessed only 51-kDa alpha chains and 56-kDa low-affinity receptors. These differences extend the evidence for functional diversity between mast cell subtypes.

摘要

通过SDS-PAGE对来自纯化大鼠肠黏膜肥大细胞（IMMC）和腹膜肥大细胞（PMC）群体的高亲和力（α链）和低亲和力IgE受体进行了表征。比较了受体表达和分子量。IMMC产生了高亲和力受体的59千道尔顿（kDa）α链和两种形式（58、50 kDa）的低亲和力受体，而PMC仅拥有51-kDaα链和56-kDa低亲和力受体。这些差异扩展了肥大细胞亚型之间功能多样性的证据。