Brown J, Sima A A, Tze W J, Tai J, Thliveris J A
Department of Anatomy, University of Manitoba, Faculty of Medicine, Winnipeg.
J Diabet Complications. 1989 Jan-Mar;3(1):35-9. doi: 10.1016/0891-6632(89)90008-1.
Pancreatic islet cells were intraportally allotransplanted into rats 2 weeks after the induction of diabetes mellitus by streptozotocin. The effect of successful transplantation on glomerular basement membrane thickening was examined 14 months later. Four groups of animals were available for study; rats with accepted pancreatic islet transplants, rats in whom graft rejection was induced, diabetic nontransplanted rats, and age-matched normal controls. Animals with accepted grafts showed no significant basement membrane thickening when compared with age-matched normal controls, while animals with rejected grafts and nontransplanted diabetic animals showed significant glomerular basement membrane thickening compared with the other groups but were not significantly different from each other. The ability of early intraportal pancreatic islet cell allotransplantation to prevent glomerular basement membrane thickening indicates that the glycemic control achieved by this approach is superior to glycemic control by traditional insulin therapy. The results of this study confirm that early pancreatic islet allotransplantation can prevent the development of glomerular basement membrane thickening in diabetic recipient rats.
在通过链脲佐菌素诱导糖尿病2周后，将胰岛细胞经门静脉同种异体移植到大鼠体内。14个月后检查成功移植对肾小球基底膜增厚的影响。有四组动物可供研究：接受胰岛移植的大鼠、诱导移植排斥的大鼠、未移植的糖尿病大鼠以及年龄匹配的正常对照大鼠。与年龄匹配的正常对照相比，接受移植的动物未显示出明显的基底膜增厚，而移植排斥的动物和未移植的糖尿病动物与其他组相比显示出明显的肾小球基底膜增厚，但它们之间没有显著差异。早期经门静脉胰岛细胞同种异体移植预防肾小球基底膜增厚的能力表明，通过这种方法实现的血糖控制优于传统胰岛素治疗的血糖控制。本研究结果证实，早期胰岛同种异体移植可预防糖尿病受体大鼠肾小球基底膜增厚的发生。
