Sima A A, Chakrabarti S, Tze W J, Tai J
Department of Pathology, University of Manitoba, Winnipeg, Canada.
Diabetologia. 1988 Mar;31(3):175-81. doi: 10.1007/BF00276852.
Progressive basement membrane thickening is a characteristic structural abnormality in diabetic tissues including the retina. We examined the effect of pancreatic islet allotransplantation on basement membrane thickening and irregularities in retinal capillaries of the streptozotocin-diabetic rat. Diabetic animals received intraportal or intracerebral pancreatic islet allografts. Animals with functioning allografts demonstrated euglycaemia and a normal body weight gain during the 400-day post-transplantation period. The characteristic thickening of capillary basement membranes was completely prevented in animals with successful transplantation. The present findings suggest that islet allotransplantation may be a rational therapeutic approach in the treatment of diabetes mellitus and the prevention of ensuing secondary complications.
进行性基底膜增厚是包括视网膜在内的糖尿病组织的一种特征性结构异常。我们研究了胰岛同种异体移植对链脲佐菌素诱导糖尿病大鼠视网膜毛细血管基底膜增厚和不规则的影响。糖尿病动物接受门静脉或脑内胰岛同种异体移植。具有功能的同种异体移植动物在移植后400天期间血糖正常且体重正常增加。成功移植的动物完全预防了毛细血管基底膜的特征性增厚。目前的研究结果表明，胰岛同种异体移植可能是治疗糖尿病和预防随之而来的继发性并发症的一种合理治疗方法。
