Jay Murray F, Tyl Rochelle W, Sullivan Frank M, Tiwary Asheesh K, Carey Sandra
Murray & Associates, 5529 Perugia Circle, San Jose, CA 95138, USA.
RTI International, 3040 Cornwallis Road, Research Triangle Park, NC, USA.
Reprod Toxicol. 2014 Nov;49:202-8. doi: 10.1016/j.reprotox.2014.09.001. Epub 2014 Sep 16.
Molybdenum is an essential nutrient for humans and animals and is a constituent of several important oxidase enzymes. It is normally absorbed from the diet and to a lesser extent from drinking water and the typical human intake is around 2μg/kg bodyweight per day. No developmental toxicity studies to contemporary standards have been published and regulatory decisions have been based primarily on older studies where the nature of the test material, or the actual dose levels consumed is uncertain. In the current study the developmental toxicity of sodium molybdate dihydrate as a representative of a broad class of soluble molybdenum(VI) compounds, was given in the diet to Sprague Dawley rats in accordance with OECD Test Guideline 414. Dose levels of 0, 3, 10, 20 and 40mgMo/kgbw/day were administered from GD6 to GD20. No adverse effects were observed at any dose level on the dams, or on embryofetal survival, fetal bodyweight, or development, with no increase in malformations or variations. Significant increases in serum and tissue copper levels were observed but no toxicity related to these was observed. The NOAEL observed in this study was 40mgMo/kgbw/day, the highest dose tested.
钼是人和动物必需的营养素，是几种重要氧化酶的组成成分。它通常从饮食中吸收，从饮用水中吸收的程度较小，人体的典型摄入量约为每天2μg/kg体重。目前尚未发表符合当代标准的发育毒性研究报告，监管决策主要基于早期研究，而这些研究中测试物质的性质或实际摄入剂量水平并不确定。在本研究中，按照经合组织测试指南414，将二水合钼酸钠作为一类广泛的可溶性钼（VI）化合物的代表，添加到饲料中喂给斯普拉格-道利大鼠。从妊娠第6天至第20天给予0、3、10、20和40mg钼/kg体重/天的剂量水平。在任何剂量水平下，均未观察到对母鼠、胚胎-胎儿存活、胎儿体重或发育有不良影响，畸形或变异也未增加。观察到血清和组织铜水平显著升高，但未观察到与之相关的毒性。本研究中观察到的无可见有害作用水平为40mg钼/kg体重/天，即测试的最高剂量。
