Shojaei Nik Mohammad Hossein, Darabi Masoud, Ziaee Amir, Hajmanoochehri Fatemeh
Department of Biochemistry and Clinical Laboratories, International Branch (Aras), Tabriz University of Medical Sciences, Tabriz, IR Iran.
Liver and Gastrointestinal Disease Research Center, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, IR Iran.
Int J Endocrinol Metab. 2014 Jun 10;12(3):e16967. doi: 10.5812/ijem.16967. eCollection 2014 Jul.
Subclinical hypothyroidism (SCH) is a metabolic disorder characterized by elevated TSH level but normal T4 level. Some previous studies suggest that SCH is associated with inflammation.
The present study aimed to compare lipid serum levels in SCH patients and normal participants, also explore possible association between SCH and the two inflammatory markers hs-CRP and PLA2-IIA.
This study was performed on 77 women aged 20-45 (39 with SCH and 38 in the control group). TSH and T4 levels were measured by electrochemiluminescenceassay. Lipid profiles were analyzed using enzymatic-colorimetric methods. Hs-CRP and PLA2-IIA were determined using the ELISA method. IBM SPSS 19.0 was used for statistical analysis.
Serum levels of TG, cholesterol, and LDL were higher in the SCH group than the control group. However, there was no significant difference between the two groups for HDL level. Likewise, no difference was observed for the serum level of hs-CRP. PLA2-IIA mean value was higher in the SCH group.
SCH is associated with increased level of PLA2-IIA, which is independent of BMI. The stronger association of SCH with PLA2-IIA than with hs-CRP indicates that PLA2-IIA is an inducer of inflammation while hs-CRP is not.
亚临床甲状腺功能减退症（SCH）是一种代谢紊乱疾病，其特征为促甲状腺激素（TSH）水平升高但甲状腺素（T4）水平正常。先前的一些研究表明，SCH与炎症有关。
本研究旨在比较SCH患者和正常参与者的血脂水平，并探讨SCH与两种炎症标志物高敏C反应蛋白（hs-CRP）和磷脂酶A2-IIA（PLA2-IIA）之间可能存在的关联。
本研究对77名年龄在20至45岁之间的女性进行（39名SCH患者和38名对照组患者）。通过电化学发光法测定TSH和T4水平。使用酶比色法分析血脂谱。采用酶联免疫吸附测定法（ELISA）测定hs-CRP和PLA2-IIA。使用IBM SPSS 19.0进行统计分析。
SCH组的甘油三酯（TG）、胆固醇和低密度脂蛋白（LDL）血清水平高于对照组。然而，两组之间的高密度脂蛋白（HDL）水平无显著差异。同样，hs-CRP的血清水平也未观察到差异。SCH组的PLA2-IIA平均值较高。
SCH与PLA2-IIA水平升高有关，且与体重指数（BMI）无关。SCH与PLA2-IIA的关联比与hs-CRP的关联更强，这表明PLA2-IIA是炎症诱导物，而hs-CRP不是。
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