Champagne E, Takihara Y, Sagman U, de Sousa J, Burrow S, Lewis W H, Mak T W, Minden M D
Department of Bioresearch, Ontario Cancer Institute, Toronto, Canada.
Blood. 1989 May 1;73(6):1672-6.
Two T-ALL patients carrying a t(11;14)(p13;q11) translocation were analyzed. Southern blotting experiments demonstrated that both patients had rearranged their J delta genes and that the translocation involved the delta locus in both cases. In one patient, cloning, restriction mapping, and sequencing showed that the translocation occurred on a D delta 1-D delta 2-J delta 2 rearranged gene. In addition, the rearrangement on chromosome 11 occurred in both patients within a segment of less than or equal to 2 kb showing the presence in this region of a point of recurrent recombination.
对两名携带t(11;14)(p13;q11)易位的T-ALL患者进行了分析。Southern印迹实验表明，两名患者的Jδ基因均发生了重排，且在这两例中易位均涉及δ基因座。在一名患者中，克隆、限制性图谱分析和测序显示易位发生在一个Dδ1-Dδ2-Jδ2重排基因上。此外，两名患者11号染色体上的重排均发生在小于或等于2 kb的片段内，表明该区域存在一个反复重组点。
