伴有皮下受累的眼附属器结外边缘区淋巴瘤。

Extranodal marginal zone lymphoma from ocular adnexae with subcutaneous involvement.

作者信息

Beltrán Brady E, Castillo Jorge J, Quiñones Pilar, Morales Domingo, Paredes Antonio, Nieto Giuliana, Miranda Roberto N, Torres-Cabala Carlos A

机构信息

*Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru; †Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI; ‡Department of Pathology, Edgardo Rebagliati Martins Hospital, Lima, Peru; §Division of Dermatology, Edgardo Rebagliati Martins Hospital, Lima, Peru; Departments of ¶Hematopathology; ‖Pathology; and **Dermatology, MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Am J Dermatopathol. 2014 Nov;36(11):e189-93. doi: 10.1097/DAD.0000000000000050.

DOI:10.1097/DAD.0000000000000050

PMID:25238445

Abstract

Extranodal marginal zone lymphoma (MZL) of mucosa-associated lymphoid tissue usually originates from cutaneous or mucosal surfaces. A rare site of involvement is the subcutaneous tissue of any location. Here, we describe a 58-year-old man who presented with bilateral extranodal MZL of mucosa-associated lymphoid tissue from ocular adnexae that involved subcutaneous tissue and subsequently extended to multiple anatomical locations in the head and neck, upper back, and arm. The neoplastic cells expressed B-cell markers, and the plasma cells expressed IgG4. The unusual pattern of infiltration of this extranodal MZL and the possible significance of IgG4 expression in this case are discussed.

摘要

黏膜相关淋巴组织的结外边缘区淋巴瘤（MZL）通常起源于皮肤或黏膜表面。一个罕见的受累部位是任何部位的皮下组织。在此，我们描述一名58岁男性，其双侧眼附属器黏膜相关淋巴组织结外MZL累及皮下组织，随后扩展至头颈部、上背部和手臂的多个解剖部位。肿瘤细胞表达B细胞标志物，浆细胞表达IgG4。讨论了这种结外MZL不寻常的浸润模式以及本例中IgG4表达的可能意义。