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生物标志物与癌症风险评估（BiomarCaRE）：欧洲生物标志物与癌症风险评估项目的基本原理和设计，该项目涵盖来自13个欧洲国家的30万名参与者。

BiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries.

作者信息

Zeller Tanja, Hughes Maria, Tuovinen Tarja, Schillert Arne, Conrads-Frank Annette, Ruijter Hester den, Schnabel Renate B, Kee Frank, Salomaa Veikko, Siebert Uwe, Thorand Barbara, Ziegler Andreas, Breek Heico, Pasterkamp Gerard, Kuulasmaa Kari, Koenig Wolfgang, Blankenberg Stefan

机构信息

Clinic for General and Interventional Cardiology, University Heart Centre Hamburg, Martinistr. 52, 20246, Hamburg, Germany,

出版信息

Eur J Epidemiol. 2014 Oct;29(10):777-90. doi: 10.1007/s10654-014-9952-x. Epub 2014 Sep 20.

DOI:10.1007/s10654-014-9952-x
PMID:25238720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4197377/
Abstract

Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role towards personalised medicine remains uncertain. Biomarker for Cardiovascular Risk Assessment in Europe (BiomarCaRE) is an European collaborative research project with the primary objective to assess the value of established and emerging biomarkers for cardiovascular risk prediction. BiomarCaRE integrates clinical and epidemiological biomarker research and commercial enterprises throughout Europe to combine innovation in biomarker discovery for cardiovascular disease prediction with consecutive validation of biomarker effectiveness in large, well-defined primary and secondary prevention cohorts including over 300,000 participants from 13 European countries. Results from this study will contribute to improved cardiovascular risk prediction across different European populations. The present publication describes the rationale and design of the BiomarCaRE project.

摘要

生物标志物被视为增强心血管风险评估的工具。然而，生物标志物在欧洲风险评分之外的风险评估中的价值、它们在不同欧洲地区的比较影响以及它们在个性化医疗中的作用仍不明确。欧洲心血管风险评估生物标志物（BiomarCaRE）是一个欧洲合作研究项目，其主要目标是评估已确立和新兴的生物标志物对心血管风险预测的价值。BiomarCaRE整合了全欧洲的临床和流行病学生物标志物研究以及商业企业，将心血管疾病预测生物标志物发现方面的创新与在大型、明确界定的一级和二级预防队列中对生物标志物有效性的连续验证相结合，这些队列包括来自13个欧洲国家的30多万参与者。这项研究的结果将有助于改善不同欧洲人群的心血管风险预测。本出版物描述了BiomarCaRE项目的基本原理和设计。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7e/4197377/2bf5d98cd8a3/10654_2014_9952_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7e/4197377/7c892d40b11e/10654_2014_9952_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7e/4197377/f51ce4222c7a/10654_2014_9952_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7e/4197377/b2c73b0d51ff/10654_2014_9952_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7e/4197377/2bf5d98cd8a3/10654_2014_9952_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7e/4197377/7c892d40b11e/10654_2014_9952_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7e/4197377/f51ce4222c7a/10654_2014_9952_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7e/4197377/b2c73b0d51ff/10654_2014_9952_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e7e/4197377/2bf5d98cd8a3/10654_2014_9952_Fig4_HTML.jpg

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