Department of Surgery, National University Singapore (NUS), Singapore, Singapore.
Neth Heart J. 2013 Oct;21(10):467-71. doi: 10.1007/s12471-013-0462-3.
Cardiovascular disease is a major public health problem worldwide. Its growing burden is particularly ominous in Asia, due to increasing rates of major risk factors such as diabetes, obesity and smoking. There is an urgent need for early identification and treatment of individuals at risk of adverse cardiovascular events. Plasma extracellular vesicle proteins are novel biomarkers that have been shown to be useful in the diagnosis, risk stratification and prognostication of patients with cardiovascular disease. Ongoing parallel biobank initiatives in European (the Netherlands) and Asian (Singapore) populations offer a unique opportunity to validate these biomarkers in diverse ethnic groups.
心血管疾病是全球主要的公共卫生问题。由于糖尿病、肥胖和吸烟等主要危险因素的发病率不断上升，亚洲地区的心血管疾病负担日益加重，情况尤为严峻。因此，迫切需要早期识别和治疗有不良心血管事件风险的个体。血浆细胞外囊泡蛋白是一种新型生物标志物，已被证明对心血管疾病患者的诊断、风险分层和预后具有一定的临床价值。目前，欧洲（荷兰）和亚洲（新加坡）人群正在开展平行的生物样本库研究，这为在不同种族人群中验证这些生物标志物提供了独特的机会。
