Golinvaux Nicholas S, Bohl Daniel D, Basques Bryce A, Baumgaertner Michael R, Grauer Jonathan N
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, PO Box 208071, New Haven, CT, 06520-8071, USA.
Clin Orthop Relat Res. 2015 Mar;473(3):1043-51. doi: 10.1007/s11999-014-3945-7. Epub 2014 Sep 20.
Diabetes and hip fractures in geriatric patients are common, and many elderly patients have a history of diabetes. However, the influence of diabetes on surgical complications may vary based on which particular type of diabetes a patient has. To our knowledge, no prior study has stratified patients with diabetes to compare patients with noninsulin-dependent and insulin-dependent diabetes regarding rates of postoperative adverse events, length of hospitalization, and readmission rate after surgical stabilization of hip fractures in geriatric patients.
QUESTIONS/PURPOSES: We asked whether patients with noninsulin-dependent or insulin-dependent diabetes are at increased risk (1) of sustaining an aggregated serious adverse event, aggregated minor adverse event, extended length of stay, or hospital readmission within 30 days of hip fracture surgery; (2) of experiencing any individual serious adverse event within 30 days of hip fracture surgery; and (3) of experiencing any individual minor adverse event within 30 days of hip fracture surgery.
Patients older than 65 years undergoing surgery for hip fracture between 2005 and 2012 were identified (n = 9938) from the American College of Surgeons National Surgical Quality Improvement Program(®) database. This database reports events within 30 days of the surgery. Demographics were compared between three groups of patients: patients with noninsulin-dependent diabetes, patients with insulin-dependent diabetes, and patients without diabetes. Patients without diabetes served as the reference group, and the relative risks for aggregated serious adverse events, aggregated minor adverse events, length of stay greater than 9 days, and readmission within 30 days were calculated for patients with noninsulin-dependent and with insulin-dependent diabetes. We then calculated relative risks for each specific serious adverse event and minor adverse event using multivariate analyses.
Patients with noninsulin-dependent and insulin-dependent diabetes were at no greater risk of sustaining an aggregated serious adverse event, aggregated minor adverse event, extended postoperative length of stay, or readmission. Among individual serious adverse events, only postoperative myocardial infarction was found to be increased in the diabetic groups (relative risk [RR] = 1.9 for noninsulin-dependent diabetes, 95% CI, 1.3-2.8; RR = 1.5 for insulin-dependent diabetes, CI, 0.9-2.6; p = 0.003). Patients with noninsulin-dependent and insulin-dependent diabetes were at no greater risk of sustaining any individual minor adverse event.
Despite previously reported and perceived risks associated with diabetes, we found little difference in terms of perioperative risk among geriatric patients with hip fracture with noninsulin-dependent or insulin-dependent diabetes relative to patients without diabetes. Clinically, the implications of these findings will help to improve, specify, and increase the efficiency of the preoperative workup and counseling of patients with diabetes who need hip fracture surgery.
Level III, case-control study. See Instructions for Authors for a complete description of levels of evidence.
老年患者中的糖尿病和髋部骨折很常见,许多老年患者有糖尿病病史。然而,糖尿病对手术并发症的影响可能因患者所患糖尿病的具体类型而异。据我们所知,之前没有研究对糖尿病患者进行分层,以比较非胰岛素依赖型和胰岛素依赖型糖尿病患者在老年髋部骨折手术稳定后的术后不良事件发生率、住院时间和再入院率。
问题/目的:我们询问非胰岛素依赖型或胰岛素依赖型糖尿病患者是否有更高风险:(1)在髋部骨折手术后30天内发生严重不良事件、轻微不良事件、住院时间延长或再次入院;(2)在髋部骨折手术后30天内发生任何一种严重不良事件;(3)在髋部骨折手术后30天内发生任何一种轻微不良事件。
从美国外科医师学会国家外科质量改进计划(®)数据库中识别出2005年至2012年间接受髋部骨折手术的65岁以上患者(n = 9938)。该数据库报告手术30天内的事件。比较了三组患者的人口统计学特征:非胰岛素依赖型糖尿病患者、胰岛素依赖型糖尿病患者和无糖尿病患者。无糖尿病患者作为参照组,计算非胰岛素依赖型和胰岛素依赖型糖尿病患者发生严重不良事件、轻微不良事件、住院时间超过9天和30天内再入院的相对风险。然后,我们使用多变量分析计算每种特定严重不良事件和轻微不良事件的相对风险。
非胰岛素依赖型和胰岛素依赖型糖尿病患者发生严重不良事件、轻微不良事件、术后住院时间延长或再入院的风险并无增加。在个体严重不良事件中,仅发现糖尿病组术后心肌梗死发生率增加(非胰岛素依赖型糖尿病的相对风险[RR] = 1.9,95%可信区间,1.3 - 2.8;胰岛素依赖型糖尿病的RR = 1.5,可信区间,0.9 - 2.6;p = 0.003)。非胰岛素依赖型和胰岛素依赖型糖尿病患者发生任何一种轻微不良事件的风险并无增加。
尽管之前报道了与糖尿病相关的风险且人们也意识到这些风险,但我们发现,与无糖尿病患者相比,非胰岛素依赖型或胰岛素依赖型糖尿病的老年髋部骨折患者围手术期风险差异不大。临床上,这些发现的意义将有助于改进、明确并提高对需要进行髋部骨折手术的糖尿病患者术前检查和咨询的效率。
III级,病例对照研究。有关证据水平的完整描述,请参阅作者须知。