Izumi Yasushi, Furuse Mikio
Division of Cell Biology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Division of Cell Biology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan; Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, Japan.
Semin Cell Dev Biol. 2014 Dec;36:186-93. doi: 10.1016/j.semcdb.2014.09.009. Epub 2014 Sep 17.
Septate junctions (SJs) are specialized intercellular junctions that function as permeability barriers to restrict the free diffusion of solutes through the paracellular routes in invertebrate epithelia. SJs are subdivided into several morphological types that vary among different animal phyla. In several phyla, different types of SJ have been described in different epithelia within an individual. Arthropods have two types of SJs: pleated SJs (pSJs) and smooth SJs (sSJs), found in ectodermally and endodermally derived epithelia, respectively. Several lines of Drosophila research have identified and characterized a large number of pSJ-associated proteins. Two sSJ-specific proteins have been recently reported. Molecular dissection of SJs in Drosophila and animals in other phyla will lead to a better understanding of the functional differences among SJ types and of evolutionary aspects of these permeability barriers.
分隔连接（SJs）是一种特殊的细胞间连接，在无脊椎动物上皮中作为通透性屏障，限制溶质通过细胞旁途径自由扩散。分隔连接可细分为几种形态类型，不同动物门之间存在差异。在几个门中，个体内不同上皮中已描述了不同类型的分隔连接。节肢动物有两种类型的分隔连接：褶皱分隔连接（pSJs）和平滑分隔连接（sSJs），分别存在于外胚层和内胚层来源的上皮中。多项果蝇研究已鉴定并表征了大量与褶皱分隔连接相关的蛋白质。最近报道了两种平滑分隔连接特异性蛋白质。对果蝇和其他门动物中分隔连接的分子剖析将有助于更好地理解分隔连接类型之间的功能差异以及这些通透性屏障的进化方面。
