在痴呆症患者和养老院居民中频繁使用阿片类药物：对丹麦所有老年人口的研究。
Frequent use of opioids in patients with dementia and nursing home residents: A study of the entire elderly population of Denmark.
机构信息
Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet-University of Copenhagen, Copenhagen, Denmark.
National Centre for Register-based Research, Aarhus University, School of Business and Social Sciences, Aarhus, Denmark.
出版信息
Alzheimers Dement. 2015 Jun;11(6):691-9. doi: 10.1016/j.jalz.2014.06.013. Epub 2014 Sep 16.
BACKGROUND
Pain is believed to be undertreated in patients with dementia; however, no larger studies have been conducted. The aim was to investigate prevalent use of opioids in elderly with and without dementia in the entire elderly population of Denmark.
METHOD
A register-based cross-sectional study in the entire elderly (≥65 years) population in 2010 was conducted. Opioid use among elderly with dementia (N = 35,455) was compared with elderly without (N = 870,645), taking age, sex, comorbidity, and living status into account.
RESULTS
Nursing home residents (NHRs) used opioids most frequently (41%), followed by home-living patients with dementia (27.5%) and home-living patients without dementia (16.9%). Buprenorphine and fentanyl (primarily patches) were commonly used among NHRs (18.7%) and home-living patients with dementia (10.7%) but less often by home-living patients without dementia (2.4%).
CONCLUSIONS
Opioid use in the elderly Danish population was frequent but particularly in patients with dementia and NHR, which may challenge patient safety and needs further investigation.
背景
据信痴呆症患者的疼痛治疗不足；然而，尚未进行更大规模的研究。目的是调查丹麦所有老年人群中患有和不患有痴呆症的老年患者中阿片类药物的普遍使用情况。
方法
2010 年进行了一项基于登记的全老年（≥65 岁）人群的横断面研究。在考虑年龄、性别、合并症和居住状况的情况下，比较了痴呆症老年患者（N=35455）和无痴呆症老年患者（N=870645）中阿片类药物的使用情况。
结果
养老院居民（NHR）使用阿片类药物最频繁（41%），其次是居住在养老院的痴呆症患者（27.5%）和居住在养老院的无痴呆症患者（16.9%）。丁丙诺啡和芬太尼（主要是贴片）在 NHR（18.7%）和居住在养老院的痴呆症患者（10.7%）中常用，但在居住在养老院的无痴呆症患者中使用较少（2.4%）。
结论
丹麦老年人群中阿片类药物的使用较为频繁，但在痴呆症患者和 NHR 中更为常见，这可能会对患者安全构成挑战，需要进一步调查。
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