伴有恶性胸腔积液的肺腺癌中表皮生长因子受体（EGFR）突变的频率：EGFR突变对癌症生物学行为的影响
Frequency of EGFR mutations in lung adenocarcinoma with malignant pleural effusion: Implication of cancer biological behaviour regulated by EGFR mutation.
作者信息
Zou JianYong, Bella Amos Ela, Chen ZhenGuang, Han XiangQian, Su ChunHua, Lei YiYan, Luo HongHe
机构信息
Department of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Department of Thoracic Surgery, Cancer Centre of Sun Yat-Sen University, Guangzhou, China.
出版信息
J Int Med Res. 2014 Oct;42(5):1110-7. doi: 10.1177/0300060514539273.
OBJECTIVE
A retrospective single-centre study to compare the clinical features of patients with lung adenocarcinoma with and without epidermal growth factor receptor (EGFR) mutations.
METHODS
Pretreatment medical records of patients with lung adenocarcinoma were reviewed. DNA was extracted from paraffin wax-embedded tumour tissue for analysis of EGFR mutations. Malignant pleural effusion (MPE) was diagnosed by cytopathological testing of pleural fluid.
RESULTS
EGFR mutations (19-Del and L858R) were recorded in 81/283 patients (28.6%). MPE was found in 42/283 patients (14.8%). In patients with stage IV disease, the frequency of EGFR mutations was higher in those with MPE than in those without MPE. EGFR mutations were independently associated with female sex, no history of smoking and presence of MPE.
CONCLUSIONS
There was a positive association between EGFR mutation and the presence of MPE. EGFR mutations may play an important role in the formation of MPE.
目的
进行一项回顾性单中心研究，比较有和没有表皮生长因子受体（EGFR）突变的肺腺癌患者的临床特征。
方法
回顾肺腺癌患者的预处理病历。从石蜡包埋的肿瘤组织中提取DNA，用于分析EGFR突变。通过胸水的细胞病理学检测诊断恶性胸腔积液（MPE）。
结果
283例患者中有81例（28.6%）记录有EGFR突变（19-缺失和L858R）。283例患者中有42例（14.8%）发现有MPE。在IV期疾病患者中，有MPE的患者EGFR突变频率高于无MPE的患者。EGFR突变与女性、无吸烟史和存在MPE独立相关。
结论
EGFR突变与MPE的存在呈正相关。EGFR突变可能在MPE的形成中起重要作用。
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