Ogbonnaya Ebere Sunny, Peev Nikolay, Nagaraja Sanjoy, Dardis Ronan
Department of Neurosurgery, University Hospital Coventry and Warwickshire, Coventry, Coventry, UK.
Department of Neurosurgery, Salford Royal Hospital, Manchester, Manchester, UK.
BMJ Case Rep. 2014 Sep 19;2014:bcr2014205922. doi: 10.1136/bcr-2014-205922.
In recent years, an increasing number of patients are treated with radiation. In the early era of radiotherapy, which began soon after X-rays were discovered by Roentgen in 1895, tumours were irradiated with high doses of X-rays in a single fraction. The major initial setback was the damage caused to normal tissues; however, in recent times the use of stereotactic radiosurgery, which delivers high doses of radiation precisely to abnormal tissue targets while sparing the surrounding normal brain tissue, and particularly for surgically inaccessible tumours, has taken centre stage. Prophylactic whole brain radiation (in conjunction with aggressive chemotherapy) for childhood acute lymphoblastic leukaemia has been shown to improve patient survival, however, this is associated with complications in survivors. We report an interesting case of one of the longest survivors who has had double complications from radiotherapy-based interventions.
近年来,接受放疗的患者数量日益增多。在放射治疗的早期,即1895年伦琴发现X射线后不久便开始了,肿瘤接受单次大剂量X射线照射。最初的主要挫折是对正常组织造成的损伤;然而,近年来,立体定向放射外科的应用已成为焦点,它能将高剂量辐射精确地传递到异常组织靶点,同时 sparing周围正常脑组织,尤其适用于手术难以触及的肿瘤。对于儿童急性淋巴细胞白血病,预防性全脑放疗(联合积极化疗)已被证明可提高患者生存率,然而,这与幸存者的并发症相关。我们报告了一例有趣的病例,该患者是放疗相关干预导致双重并发症的最长幸存者之一。 (注:原文中“sparing”疑似拼写错误,可能是“sparing”,正确的可能是“sparing”,译为“ sparing”,保留周围正常脑组织。)