Innamorati Marco, Rihmer Zoltan, Akiskal Hagop, Gonda Xenia, Erbuto Denise, Belvederi Murri Martino, Perugi Giulio, Amore Mario, Girardi Paolo, Pompili Maurizio
Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant׳Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Department of Clinical and Theoretical Mental Health, Kútvölgyi Clinical Center, Semmelweis University, Budapest, Hungary.
J Affect Disord. 2015 Jan 1;170:161-5. doi: 10.1016/j.jad.2014.08.042. Epub 2014 Sep 6.
The aim of the present study was to assess sociodemographic and clinical differences between inpatients with major mood disorders (bipolar disorder - BD - and major depression - MDD) and the cyclothymic phenotype (CYC), and pure BDs or MDDs.
Participants were 281 adult inpatients (134 men and 147 women) consecutively admitted to the Department of Psychiatry of the Sant׳Andrea University Hospital in Rome, Italy, between January 2008 and June 2010. The patients completed the Hamilton Scale for Depression (HAMD17), the Young Mania Rating Scale, the TEMPS-A (Temperament Evaluation of the Memphis, Pisa, Paris and San Diego-Autoquestionnaire), and the Beck Hopelessness Scale.
38.7% of the MDD patients and 48.3% of the BD patients satisfied criteria to be included in the cyclothymic groups. Above 92% of the patients with the cyclothymic phenotype reported suicidal ideation at the item #3 of the HAMD17. Furthermore, patients with the cyclothymic phenotype reported higher hopelessness than other patients.
Our results are potentially limited by the small number of MDD-CYC patients included in the sample.
Our results support the clinical usefulness of the concept of soft bipolar spectrum. Patients with the cyclothymic phenotype differ from pure MDD patients and BD patients for temperamental profile and clinical variables.
本研究旨在评估患有重度心境障碍（双相情感障碍 - BD - 和重度抑郁症 - MDD）的住院患者与环性心境障碍表型（CYC）以及单纯BD或MDD患者之间的社会人口统计学和临床差异。
参与者为2008年1月至2010年6月期间连续入住意大利罗马圣安德烈亚大学医院精神科的281名成年住院患者（134名男性和147名女性）。患者完成了汉密尔顿抑郁量表（HAMD17）、杨氏躁狂评定量表、TEMPS - A（孟菲斯、比萨、巴黎和圣地亚哥气质评估 - 自填问卷）以及贝克绝望量表。
38.7%的MDD患者和48.3%的BD患者符合纳入环性心境障碍组的标准。超过92%的具有环性心境障碍表型的患者在HAMD17的第3项报告有自杀观念。此外，具有环性心境障碍表型的患者比其他患者报告有更高的绝望感。
我们的结果可能受样本中纳入的MDD - CYC患者数量较少的限制。
我们的结果支持软双相谱系概念的临床实用性。具有环性心境障碍表型的患者在气质特征和临床变量方面与单纯MDD患者和BD患者不同。
