Montal Mauricio
Section of Neurobiology, University of California San Diego, La Jolla, CA 92093, USA.
Trends Mol Med. 2014 Nov;20(11):602-3. doi: 10.1016/j.molmed.2014.09.005. Epub 2014 Sep 18.
Botulinum neurotoxin causes botulism, and the only effective antidote is the antitoxin. Botulinum neurotoxins are disulfide linked di-chain proteins encompassing a light chain Zn2+-protease that is translocated by a heavy chain channel from the synaptic vesicle lumen into the neuronal cytosol where it acts. Protease release from the channel is required for toxicity. The Thioredoxin Reductase-Thioredoxin system cleaves the interchain disulfide, and its inhibition prevents neurotoxicity, and may provide novel strategies for chemoprophylaxis and therapy.
肉毒杆菌神经毒素可导致肉毒中毒,而唯一有效的解毒剂是抗毒素。肉毒杆菌神经毒素是通过二硫键连接的双链蛋白,包含一种轻链Zn2+蛋白酶,该蛋白酶通过重链通道从突触小泡腔转运到神经元胞质溶胶中发挥作用。毒性需要蛋白酶从通道中释放。硫氧还蛋白还原酶-硫氧还蛋白系统可切割链间二硫键,抑制该系统可预防神经毒性,并可能为化学预防和治疗提供新策略。