Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
Trends Endocrinol Metab. 2014 Dec;25(12):620-7. doi: 10.1016/j.tem.2014.08.005. Epub 2014 Sep 18.
While the role of autophagy in the physiology of endocrine organs and the development of metabolic disorders or diabetes has been investigated, the relationship between the pancreatic islet and autophagy has not been explored extensively. In this review, studies on the possible involvement of dysregulated autophagy in the pathogenesis of metabolic syndrome and diabetes will be summarized with an emphasis on the autophagic process in pancreatic islet β cells. Novel findings regarding the role of autophagy in human β cell pathology and the development of type 2 diabetes (T2D) characterized by islet amyloid deposition will be discussed. Careful design of agents enhancing autophagic activity in β cells might serve as a novel approach towards therapeutics for the treatment of diabetes.
虽然自噬在内分泌器官的生理学和代谢紊乱或糖尿病的发展中的作用已经被研究过，但胰岛和自噬之间的关系还没有被广泛探索。在这篇综述中，我们将总结关于失调的自噬可能参与代谢综合征和糖尿病发病机制的研究，重点是胰岛β细胞中的自噬过程。我们将讨论自噬在人类β细胞病理学和以胰岛淀粉样沉积为特征的 2 型糖尿病（T2D）发病机制中的作用的新发现。精心设计增强β细胞自噬活性的药物可能成为治疗糖尿病的新方法。
