二叔丁基过氧化物促进简单烷烃对α-氨基羰基化合物的α-烷基化反应。
Di-tert-butyl peroxide-promoted α-alkylation of α-amino carbonyl compounds by simple alkanes.
作者信息
Peng Haibo, Yu Jin-Tao, Jiang Yan, Yang Haitao, Cheng Jiang
机构信息
School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University , Changzhou 213164, People's Republic of China.
出版信息
J Org Chem. 2014 Oct 17;79(20):9847-53. doi: 10.1021/jo5017426. Epub 2014 Oct 3.
A di-tert butyl peroxide (DTBP)-promoted α-alkylation of α-amino carbonyl compounds by simple alkanes is developed, proceeding through dual sp(3) C-H bonds cleavage. The reaction was applicable for α-amino ketones and α-amino esters, providing a facile pathway for the α-functionalization of these substrates. The radical pathway is involved in this transformation.
开发了一种二叔丁基过氧化物（DTBP）促进的简单烷烃对α-氨基羰基化合物的α-烷基化反应，该反应通过双sp(3) C-H键裂解进行。该反应适用于α-氨基酮和α-氨基酯，为这些底物的α-官能化提供了一条简便途径。这种转化涉及自由基途径。
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