Choi Jae-Won, Cha Boseok, Jang Jihoon, Park Chul-Soo, Kim Bong-Jo, Lee Cheol-Soon, Lee So-Jin
Department of Psychiatry, Gyeongsang National University Hospital, Jinju, Republic of Korea.
Department of Psychiatry, Gyeongsang National University Hospital, Jinju, Republic of Korea; Department of Psychiatry, Gyeongsang National University College of medicine, Jinju, Republic of Korea.
J Affect Disord. 2015 Jan 1;170:172-7. doi: 10.1016/j.jad.2014.08.056. Epub 2014 Sep 6.
Stress plays an important role in the onset and recurrence of bipolar disorder (BD). Resilience is the ability to cope with stress or adversity. Few studies have examined resilience in BD, and this study aimed to investigate the clinical correlates of resilience in euthymic patients with BD.
A total of 62 outpatients with BD type I, II, and not otherwise specified (NOS) who were in remission and 62 healthy individuals matched with the BD group in terms of age and sex were recruited. All participants completed the Connor-Davidson Resilience Scale and Barratt Impulsiveness Scale. A psychiatrist interviewed the subjects to assess clinical characteristics. Multiple linear regression analysis was used to determine factors associated with resilience.
The BD group had significantly higher levels of impulsivity and lower levels of resilience compared with the control group. Degree of impulsivity, number of depressive episodes, Clinical Global Impression (CGI) scores, and length of education were significantly correlated with resilience. Attention impulsivity, non-planning impulsivity, and number of depressive episodes were associated with low levels of resilience, even when age, sex, length of education, and CGI scores were controlled.
Because tertiary hospital patients were recruited, the generalizability of the findings is limited.
This study shows that low levels of resilience are related to high levels of impulsivity and to an increased number of depressive episodes in euthymic patients with BD. Given the reciprocal relationship between resilience and impulsivity, efforts to enhance resilience and reduce impulsivity may make important contributions to the treatment of patients with BD.
压力在双相情感障碍（BD）的发病及复发中起重要作用。心理弹性是应对压力或逆境的能力。很少有研究探讨双相情感障碍中的心理弹性，本研究旨在调查双相情感障碍缓解期患者心理弹性的临床相关因素。
共招募了62例I型、II型及未特定型（NOS）双相情感障碍门诊缓解期患者以及62名在年龄和性别上与双相情感障碍组匹配的健康个体。所有参与者均完成了康纳-戴维森心理弹性量表和巴拉特冲动性量表。一名精神科医生对受试者进行访谈以评估临床特征。采用多元线性回归分析确定与心理弹性相关的因素。
与对照组相比，双相情感障碍组的冲动性水平显著更高，心理弹性水平更低。冲动程度、抑郁发作次数、临床总体印象（CGI）评分和受教育年限与心理弹性显著相关。即使在控制了年龄、性别、受教育年限和CGI评分后，注意冲动性、无计划冲动性和抑郁发作次数仍与低心理弹性水平相关。
由于招募的是三级医院的患者，研究结果的普遍性有限。
本研究表明，双相情感障碍缓解期患者心理弹性水平低与高冲动性及更多的抑郁发作次数有关。鉴于心理弹性与冲动性之间的相互关系，增强心理弹性和降低冲动性的努力可能对双相情感障碍患者的治疗有重要贡献。
