Department of Public Health, University of Cagliari, Italy.
Psychiatry Res. 2011 Jun 30;188(1):40-4. doi: 10.1016/j.psychres.2010.10.026. Epub 2010 Dec 4.
Few studies to date have been performed to investigate impulsivity and aggressivity in patients with bipolar disorder (BD) and borderline personality disorder (BPD); the primary aim of the present study was to evaluate the impact of co-morbidity of BPD on impulsivity and aggressivity in patients affected by BD. A total of 57 patients (male=20, female=37) affected by BD (BD-I 51%; BD-II 49%) in clinical stable remission were recruited; 28 patients were affected by BD (49.1%), 18 by BD and BPD (31.6%) and 11 (19.3%) by BD plus other personality disorders (OPD) (19.3%). They were assessed with the Structured Clinical Interview for DSM-IV (SCID)-I and SCID-II, and were evaluated by means of the Clinical Global Impression (CGI)-severity and Global Assessment Functioning (GAF) scales, the Barratt Impulsivity Scale (BIS-11) and the Aggression Questionnaire (AQ). Mean total scores were significantly higher among BD/BPD patients with respect to BD and to BD/OPD, both on the BIS-11 and the AQ; the rate of attempted suicides was approximately three times higher in BD/BPD patients with respect to BD and 7.6 times higher than in BD/OPD patients. The results of our study suggest that patients with co-morbid BD and BPD are more impulsive and aggressive. Furthermore, this co-morbid condition may be a risk factor for suicidality.
迄今为止，很少有研究调查双相情感障碍（BD）和边缘型人格障碍（BPD）患者的冲动性和攻击性；本研究的主要目的是评估 BPD 共病对受 BD 影响的患者冲动性和攻击性的影响。共招募了 57 名（男性=20，女性=37）处于临床稳定缓解期的 BD 患者（BD-I 占 51%；BD-II 占 49%）；28 名患者受 BD 影响（49.1%），18 名受 BD 和 BPD 影响（31.6%），11 名受 BD 和其他人格障碍（OPD）影响（19.3%）。他们接受了 DSM-IV（SCID-I 和 SCID-II）的结构临床访谈，并通过临床总体印象（CGI-严重程度和总体功能评估（GAF）量表、Barratt 冲动量表（BIS-11）和攻击问卷（AQ）进行评估。BD/BPD 患者的 BIS-11 和 AQ 总分均显著高于 BD 和 BD/OPD 患者；BD/BPD 患者的自杀未遂率约为 BD 患者的 3 倍，为 BD/OPD 患者的 7.6 倍。我们的研究结果表明，患有共病 BD 和 BPD 的患者更冲动和具有攻击性。此外，这种共病状况可能是自杀的一个风险因素。
