San Gabriel Maria Chona P, Eddula-Changala Bharathi, Tan Yonghong, Longshore Carrol T
From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, Elmhurst, NY.
J ECT. 2015 Sep;31(3):197-200. doi: 10.1097/YCT.0000000000000184.
We present the case of a middle-aged man with a chronic history of schizoaffective disorder, depressed type, stable on a second-generation antipsychotic. Psychotic symptoms recurred contingent to medication noncompliance necessitating hospitalization. Treatment was complicated by the development of neuroleptic malignant syndrome (NMS). In addition, subsequent medication rechallenges failed because of recurrent rhabdomyolysis and atypical NMS. Electroconvulsive therapy (ECT) treatment was initiated, affording remission of psychotic symptoms and nonrecurrence of NMS and rhabdomyolysis. Our experience confirmed the efficacy of ECT treatment in providing symptom relief of psychosis complicated by recurrent episodes of NMS and atypical NMS. Likewise, it illustrated the efficacy of ECT treatment for rhabdomyolysis.
我们报告了一例患有精神分裂症伴抑郁型慢性病史的中年男性病例，其病情在使用第二代抗精神病药物时保持稳定。因不遵医嘱服药导致精神病症状复发，需要住院治疗。治疗过程因出现抗精神病药物恶性综合征（NMS）而变得复杂。此外，由于复发性横纹肌溶解症和非典型NMS，随后的药物再激发试验失败。开始进行电休克治疗（ECT），使精神病症状得到缓解，且NMS和横纹肌溶解症未再复发。我们的经验证实了ECT治疗在缓解伴有复发性NMS和非典型NMS发作的精神病症状方面的有效性。同样，它也说明了ECT治疗对横纹肌溶解症的疗效。
