Srivastava Ashish, Borkar Hirabai A, Chandak Sumitkumar
Institute of Psychiatry and Human Behaviour, Bambolim, Goa, India.
Psychiatry Clin Neurosci. 2009 Feb;63(1):119-21. doi: 10.1111/j.1440-1819.2008.01894.x. Epub 2008 Dec 1.
A case of a male patient with schizophrenic illness who developed neuroleptic malignant syndrome (NMS) following treatment with olanzapine is reported. Although typical neuroleptics are more frequently associated with NMS, atypical antipsychotics may also cause NMS. Case reports have been published concerning NMS and clozapine,(1) risperidone(2) and olanzapine.(3-6) This case report emphasizes the importance of being cautious when rapidly increasing doses of olanzapine are used in patients with psychiatric illnesses.
报告了一例男性精神分裂症患者，在使用奥氮平治疗后发生了抗精神病药恶性综合征（NMS）。虽然典型抗精神病药与NMS的关联更为常见，但非典型抗精神病药也可能导致NMS。关于NMS与氯氮平、（1）利培酮（2）和奥氮平（3 - 6）的病例报告已有发表。本病例报告强调了在精神疾病患者中快速增加奥氮平剂量时要谨慎的重要性。
