Gan Ren-You, Li Hua-Bin
School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Int J Mol Sci. 2014 Sep 19;15(9):16698-718. doi: 10.3390/ijms150916698.
Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated protein kinase (AMPK)-related protein kinases, and possesses versatile biological functions. LKB1 gene is mutated in many cancers, and its protein can form different protein complexes with different cellular localizations in various cell types. The expression of LKB1 can be regulated through epigenetic modification, transcriptional regulation and post-translational modification. LKB1 dowcnstream pathways mainly include AMPK, microtubule affinity regulating kinase (MARK), salt-inducible kinase (SIK), sucrose non-fermenting protein-related kinase (SNRK) and brain selective kinase (BRSK) signalings, etc. This review, therefore, mainly discusses recent studies about the expression, regulation, downstream signaling and cancer suppressive function of LKB1, which can be helpful for better understanding of this molecular and its significance in cancers.
肝脏激酶B1（LKB1），作为一种丝氨酸/苏氨酸激酶，已被确定为许多癌细胞中的关键抑癌基因。它是13种AMP激活蛋白激酶（AMPK）相关蛋白激酶的主要上游激酶，具有多种生物学功能。LKB1基因在许多癌症中发生突变，其蛋白在不同细胞类型中可形成具有不同细胞定位的不同蛋白复合物。LKB1的表达可通过表观遗传修饰、转录调控和翻译后修饰进行调节。LKB1下游通路主要包括AMPK、微管亲和力调节激酶（MARK）、盐诱导激酶（SIK）、蔗糖非发酵蛋白相关激酶（SNRK）和脑选择性激酶（BRSK）信号等。因此，本综述主要讨论了关于LKB1的表达、调控、下游信号传导和抑癌功能的最新研究，这有助于更好地理解该分子及其在癌症中的意义。
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