Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK.
BMC Biol. 2013 Apr 15;11:36. doi: 10.1186/1741-7007-11-36.
The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003. This finding represented the first clear link between AMPK and cancer. Here we briefly discuss how this discovery came about, and describe some of the insights, especially into the role of AMPK in cancer, that have followed from it.
2003 年，《生物学杂志》上的一篇文章报道了一个包含肿瘤抑制因子 LKB1 的复合物的鉴定，该复合物是代谢应激激活 AMP 激活的蛋白激酶（AMPK）所必需的关键上游激酶。这一发现首次将 AMPK 与癌症联系起来。在这里，我们简要讨论一下这一发现是如何产生的，并描述了由此产生的一些见解，特别是 AMPK 在癌症中的作用。
