Sharma Deepak, Murki Anuradha, Murki Srinivas, Pratap Oleti Tejo
a Department of Neonatology , Fernandez Hospital , Hyderguda , Hyderabad , Andhra Pradesh , India and.
J Matern Fetal Neonatal Med. 2015;28(15):1774-8. doi: 10.3109/14767058.2014.968548. Epub 2014 Oct 9.
Sepsis and necrotizing enterocolitis (NEC) cause significant morbidity and mortality in the newborn. Their ill effects persist in spite of appropriate and effective antibiotic therapy. Lactoferrin as an adjunct to antibiotics in the treatment of sepsis or NEC in the newborn may improve the clinical outcomes by enhancing the host defense and modulating the inflammatory response. This review focuses on the various aspects of lactoferrin use in the newborn.
脓毒症和坏死性小肠结肠炎(NEC)在新生儿中会导致严重的发病和死亡。尽管进行了恰当有效的抗生素治疗,它们的不良影响仍然存在。乳铁蛋白作为抗生素的辅助药物用于治疗新生儿脓毒症或NEC,可能通过增强宿主防御和调节炎症反应来改善临床结局。本综述聚焦于乳铁蛋白在新生儿中的应用的各个方面。