Sharma Deepak, Shastri Sweta
a Department of Neonatology , Fernandez Hospital , Hyderabad , India .
b Department of Pediatrics , ACPM Medical College , Dhule , Maharashtra , India.
J Matern Fetal Neonatal Med. 2016 Mar;29(5):763-70. doi: 10.3109/14767058.2015.1017463. Epub 2015 Mar 17.
Neonatal sepsis and necrotizing enterocolitis (NEC) are two most important neonatal problems in nursery which constitute the bulk of neonatal mortality and morbidity. Inflammatory mediators secondary to sepsis and NEC increases morbidity, by affecting various system of body like lung, brain and eye, thus causing long term implications. Lactoferrin (LF) is a component of breast milk and multiple actions that includes antimicrobial, antiviral, anti-fungal and anti-cancer and various other actions. Few studies have been completed and a number of them are in progress for evaluation of efficacy and safety of LF in the prevention of neonatal sepsis and NEC in field of neonatology. In future, LF prophylaxis and therapy may have a significant impact in improving clinical outcomes of vulnerable preterm neonates. This review analyse the role of lactoferrin in prevention of neonatal sepsis and NEC, with emphasis on mechanism of action, recent studies and current studies going on around the globe.
新生儿败血症和坏死性小肠结肠炎（NEC）是新生儿重症监护室中两个最重要的新生儿问题，它们构成了新生儿死亡和发病的主要部分。败血症和NEC继发的炎症介质会影响身体的各个系统，如肺、脑和眼睛，从而增加发病率，造成长期影响。乳铁蛋白（LF）是母乳的一种成分，具有多种作用，包括抗菌、抗病毒、抗真菌和抗癌以及其他各种作用。在新生儿学领域，关于LF预防新生儿败血症和NEC的疗效和安全性评估，仅有少数研究完成，还有一些研究正在进行中。未来，LF预防和治疗可能会对改善脆弱早产儿的临床结局产生重大影响。本综述分析了乳铁蛋白在预防新生儿败血症和NEC中的作用，重点关注其作用机制、近期研究以及全球正在进行的当前研究。
