Wang Lei, Liu Xiu-Heng, Chen Hui, Chen Zhi-Yuan, Weng Xiao-Dong, Qiu Tao, Liu Lin
Department of Urology, Renmin Hospital of Wuhan University , Wuhan, Hubei , P.R. China.
Ren Fail. 2014 Oct;36(9):1443-8. doi: 10.3109/0886022X.2014.949766.
In kidney transplantation, renal ischemia and reperfusion injury was one of the leading factors to the development of renal fibrosis, which was the main cause of graft loss. The fibrogenic changes were associated with the long term inflammation elicited by ischemia and reperfusion injury. In the present study, we investigated the role of the Picroside II, the main active constituents of the extract of picrorrhiza scrophulariiflora roots, in attenuating renal fibrosis in a renal ischemia and reperfusion injury model. We induced ischemia and reperfusion injury in kidneys treated with or without Picroside II. We observed that inflammation and tissue fibrosis were increased in ischemia and reperfusion injury group compared to Picroside II group, however, these changes were significantly decreased by the treatment with Picroside II. We concluded that Picroside II can protect the ischemic kidney against renal fibrosis and its mechanism may be through the inhibition of the long term inflammation.
在肾移植中，肾缺血再灌注损伤是导致肾纤维化的主要因素之一，而肾纤维化是移植肾失功的主要原因。纤维化改变与缺血再灌注损伤引发的长期炎症有关。在本研究中，我们调查了胡黄连根提取物的主要活性成分胡黄连苷II在减轻肾缺血再灌注损伤模型中肾纤维化方面的作用。我们在给予或未给予胡黄连苷II的情况下诱导肾脏发生缺血再灌注损伤。我们观察到，与胡黄连苷II组相比，缺血再灌注损伤组的炎症和组织纤维化增加，然而，胡黄连苷II治疗可显著减轻这些变化。我们得出结论，胡黄连苷II可保护缺血肾脏免受肾纤维化影响，其机制可能是通过抑制长期炎症实现的。
