Roos M T, Miedema F, Eeftinck Schattenkerk J K, de Wolf F, Goudsmit J, Lange J M, Danner S A, Out T A, Schellekens P T
Neth J Med. 1989 Apr;34(3-4):132-41.
The relationship between infection with human immunodeficiency virus (HIV) and various immunological parameters was studied in: (a) healthy controls; (b) homosexual individuals from the AIDS risk group without anti-HIV antibodies; (c) idem, but with anti-HIV antibodies; (d) patients with persistent generalized lymphadenopathy (PGL); (e) patients with AIDS-related syndrome; (f) patients with AIDS and opportunistic infections. In each group, consisting of 15-20 individuals, the following parameters were studied: absolute numbers of CD4+ and CD8+ cells; ratio CD4+/CD8+; cellular immune responses as measured in vivo by delayed-type hypersensitivity (DTH) and in vitro; and antibody response in vivo after immunization with a low dose of keyhole limpet haemocyanin. Healthy HIV antibody-positive individuals and patients with persistent generalized lymphadenopathy already showed a decreased CD4+/CD8+ ratio, mainly due to an increase in the number of CD8+ cells. The ratio in the AIDS-related syndrome and AIDS groups was even lower, but this was now due to low numbers of CD4+ cells while the number of CD8+ cells was normal. The lymphocyte proliferative response was low in the HIV antibody-positive group, normal in the group with persistent generalized lymphadenopathy and profoundly decreased in the AIDS-related syndrome and AIDS groups. DTH was enhanced in the PGL group and diminished in both ARC and AIDS. Compared to healthy controls, the antibody response upon immunization with a low dose of keyhole limpet haemocyanin was depressed (although not absent) in all groups studied, even in HIV antibody-negative homosexuals. In the HIV antibody-positive group, the severity of the impairment of the various parameters of immunocompetence was not related to the presence of HIV antigenaemia.
在以下人群中研究了人类免疫缺陷病毒（HIV）感染与各种免疫参数之间的关系：（a）健康对照者；（b）来自艾滋病风险组且无抗HIV抗体的同性恋个体；（c）同上，但有抗HIV抗体；（d）持续性全身性淋巴结病（PGL）患者；（e）艾滋病相关综合征患者；（f）患有艾滋病和机会性感染的患者。在每组由15 - 20名个体组成的人群中，研究了以下参数：CD4 +和CD8 +细胞的绝对数量；CD4 + / CD8 +比值；通过体内迟发型超敏反应（DTH）和体外测量的细胞免疫反应；以及用低剂量钥孔戚血蓝蛋白免疫后体内的抗体反应。健康的HIV抗体阳性个体和持续性全身性淋巴结病患者已经表现出CD4 + / CD8 +比值降低，主要是由于CD8 +细胞数量增加。艾滋病相关综合征组和艾滋病组中的该比值甚至更低，但这现在是由于CD4 +细胞数量低而CD8 +细胞数量正常。HIV抗体阳性组中的淋巴细胞增殖反应较低，持续性全身性淋巴结病组正常，而艾滋病相关综合征组和艾滋病组则显著降低。DTH在PGL组中增强，在ARC和艾滋病组中减弱。与健康对照者相比，在所有研究组中，用低剂量钥孔戚血蓝蛋白免疫后的抗体反应均受到抑制（尽管并非完全没有），即使在HIV抗体阴性的同性恋者中也是如此。在HIV抗体阳性组中，免疫能力各项参数受损的严重程度与HIV抗原血症的存在无关。
