Zhao Haizhao, Jia Ming, Wang Zhujun, Cheng Yuping, Luo Zebin, Chen Yuanyuan, Xu Xiaojun, Yang Shilong, Tang Yongmin
Hematology. 2015 Jun;20(5):254-62. doi: 10.1179/1607845414Y.0000000202. Epub 2014 Sep 23.
Objectives The effects of NOD2 single nucleotide polymorphisms (SNPs) on Grade III-IV acute graft-versus-host disease (aGVHD) risk are somewhat contradictory in different studies. The aim of the meta-analysis was to clarify the effects of NOD2 SNPs on the incidence of Grade III-IV aGVHD. Methods We searched PubMed, EMBASE, Web of SCIENCE, WanFang and Chinese National Knowledge Infrastructure (CNKI) databases to collect eligible publications. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between NOD2 polymorphisms and Grade III-IV aGVHD risk. Results A total of nine studies from eight publications met the inclusion criteria and were included in this meta-analysis. Patient NOD2 SNPs were not associated with aGVHD risk. A tendency of higher risk to develop Grade III-IV aGVHD was found in patients with pairs NOD2 SNPs. Subgroup analyses showed that pairs NOD2 SNPs were associated with Grade III-IV aGVHD in the Caucasian population and in identical sibling donors (IS), but not in matched unrelated donors (MUD). In patients who received hematopoietic stem cell transplantation (HSCT) with T-cell depletion and gut decontamination, there was still an association between pairs NOD2 SNPs and Grade III-IV aGVHD risk. Conclusions Our meta-analysis suggests that pairs NOD2 SNPs, not patient NOD2 SNPs, may be associated with Grade III-IV aGVHD risk, especially in the Caucasian population. It is also indicated that in pairs NOD2 polymorphisms group, patients who receive HSCT from IS may experience higher risk of Grade III-IV aGVHD.
在不同研究中，NOD2单核苷酸多态性（SNP）对III-IV级急性移植物抗宿主病（aGVHD）风险的影响存在一定矛盾。本荟萃分析的目的是阐明NOD2 SNP对III-IV级aGVHD发病率的影响。方法：我们检索了PubMed、EMBASE、Web of SCIENCE、万方和中国知网（CNKI）数据库，以收集符合条件的出版物。采用比值比（OR）及95%置信区间（CI）评估NOD2多态性与III-IV级aGVHD风险之间的关联。结果：来自8篇出版物的9项研究符合纳入标准，被纳入本荟萃分析。患者NOD2 SNP与aGVHD风险无关。在具有成对NOD2 SNP的患者中，发现发生III-IV级aGVHD的风险有升高趋势。亚组分析显示，成对NOD2 SNP在白种人群和同基因同胞供者（IS）中与III-IV级aGVHD相关，但在匹配无关供者（MUD）中则不然。在接受过T细胞去除和肠道去污的造血干细胞移植（HSCT）患者中，成对NOD2 SNP与III-IV级aGVHD风险之间仍存在关联。结论：我们的荟萃分析表明，成对NOD2 SNP而非患者NOD2 SNP可能与III-IV级aGVHD风险相关，尤其是在白种人群中。还表明，在成对NOD2多态性组中，接受来自IS的HSCT的患者可能发生III-IV级aGVHD的风险更高。
