Kilari Deepak, Dale William, Mohile Supriya Gupta
Medical College of Wisconsin, Milwaukee, WI, USA.
University of Chicago, Chicago, IL, USA.
J Geriatr Oncol. 2014 Oct 1;5(4):337-42. doi: 10.1016/j.jgo.2014.09.177. Epub 2014 Sep 22.
With the aging of our population, the prevalence of prostate cancer is anticipated to rise dramatically. Consequently, physicians will be confronted with the challenges of managing prostate cancer and treatment side effects in older men. The maintenance of mobility and functional independence, which are fundamental goals of the aging patient with cancer, should not be overlooked when choosing treatments and their toxicities focused on cancer control. Consistent with the SIOG (International Society of Geriatric Oncology) guidelines, we recommend standard approaches for older patients with prostate cancer who are fit. Vulnerable patients should also receive standard treatment, provided their health status can be maintained with appropriate interventions. Treatment for frail patients should be adapted to their health status and supportive care interventions should be considered. Individualized treatment plans should take into account patient's remaining life-expectancy from coexisting comorbidities and disability, aggressiveness of the prostate cancer, treatment preferences as well as potential adverse effects of treatment.
随着我国人口老龄化，前列腺癌的患病率预计将大幅上升。因此，医生将面临管理老年男性前列腺癌及其治疗副作用的挑战。在选择以癌症控制为重点的治疗方法及其毒性时，不应忽视保持行动能力和功能独立性这一老年癌症患者的基本目标。根据老年肿瘤学国际协会（SIOG）的指南，我们建议对身体状况良好的老年前列腺癌患者采用标准治疗方法。脆弱患者也应接受标准治疗，前提是通过适当干预能够维持其健康状况。对体弱患者的治疗应根据其健康状况进行调整，并应考虑支持性护理干预措施。个性化治疗计划应考虑患者因并存的合并症和残疾而剩余的预期寿命、前列腺癌的侵袭性、治疗偏好以及治疗的潜在不良反应。
