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[使用艾日布林成功治疗转移性乳腺癌合并微血管病性溶血性贫血]

[Metastatic breast cancer with microangiopathic hemolytic anemia successfully treated by using eribulin].

作者信息

Morita Midori, Fukuda Ken-Ichiro, Konishi Tomoki, Kiuchi Jun, Umehara Seiji, Nakashima Susumu, Fujiyama Junshin, Masuyama Mamoru

机构信息

Dept. of Surgery, Saiseikai Shiga Hospital.

出版信息

Gan To Kagaku Ryoho. 2014 Sep;41(9):1139-41.

Abstract

A 48-year-old woman was diagnosed with metastatic breast carcinoma and multiple bone metastases as well as a brain metastasis in 2004. Multiple bone metastases and brain metastases were also diagnosed in 2005, 2006, and 2010, but she remained stable with the use of chemotherapy and hormonal therapy for about 8 years. In 2013, severe anemia occurred, and the patient was diagnosed with microangiopathic hemolytic anemia (MHA). She was treated with eribulin(1.4 mg/m²), and recovered successfully after treatment. Approximately 8 months have elapsed after initiating the therapy, and there has been no recurrence. MHA associated with breast cancer is very rare, and is regarded as a disease with a poor prognosis. However, eribulin could be a valid treatment for prolonging the survival of patients with MHA associated with breast cancer.

摘要

一名48岁女性于2004年被诊断为转移性乳腺癌,伴有多处骨转移及脑转移。2005年、2006年和2010年也诊断出多处骨转移和脑转移,但通过化疗和激素治疗,她病情稳定约8年。2013年,患者出现严重贫血,被诊断为微血管病性溶血性贫血(MHA)。她接受了艾日布林(1.4 mg/m²)治疗,治疗后成功康复。开始治疗后约8个月,未出现复发。与乳腺癌相关的MHA非常罕见,被认为是一种预后不良的疾病。然而,艾日布林可能是延长与乳腺癌相关的MHA患者生存期的有效治疗方法。

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