一种用于反相液相色谱的新型尿素功能化表面受限十八烷基咪唑鎓离子液体硅胶固定相。
A novel urea-functionalized surface-confined octadecylimidazolium ionic liquid silica stationary phase for reversed-phase liquid chromatography.
作者信息
Zhang Mingliang, Tan Ting, Li Zhan, Gu Tongnian, Chen Jia, Qiu Hongdeng
机构信息
Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, China.
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
出版信息
J Chromatogr A. 2014 Oct 24;1365:148-55. doi: 10.1016/j.chroma.2014.09.018. Epub 2014 Sep 16.
One-pot synthesis of surface-confined ionic liquid functionalized silica spheres was proposed using N-(3-aminopropyl)imidazole, γ-isopropyltriethoxysilane and 1-bromooctadecane as starting materials. The surface modification of the silica spheres was successful with a high surface density of octadecylimidazolium, enabling the utilization of this new urea-functionalized ionic liquid-grafted silica material as stationary phase for high-performance liquid chromatography in reversed-phase mode. The long aliphatic chain combined with the multiple polar group embedded in the ligands imparted the new stationary phase fine selectivity towards PAH isomers and polar aromatics and higher affinity for phenolic compounds. The unique features of the new material, especially the effect of the urea group on the retention were elucidated by mathematic modeling.
提出了一种以N-(3-氨丙基)咪唑、γ-异丙基三乙氧基硅烷和1-溴十八烷为起始原料一锅法合成表面受限离子液体功能化二氧化硅球的方法。成功地对二氧化硅球进行了表面改性，得到了高表面密度的十八烷基咪唑鎓，使得这种新型尿素功能化离子液体接枝二氧化硅材料能够用作反相模式高效液相色谱的固定相。长脂肪链与配体中嵌入的多个极性基团相结合，赋予了这种新型固定相对多环芳烃异构体和极性芳烃良好的选择性以及对酚类化合物更高的亲和力。通过数学建模阐明了这种新材料的独特特性，特别是脲基对保留的影响。
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