Anand Veena, Nair P M C
Department of Pediatrics, Sree Gokulam Medical College and Research Foundation, Thiruvananthapuram, Kerala, India.
J Pediatr Neurosci. 2014 May;9(2):97-9. doi: 10.4103/1817-1745.139261.
Early detection of predictors of adverse outcome will be helpful for neonatologists to plan management, follow up and rehabilitation in advance so that neurological disability can be minimised.
The purpose of this study was to determine the factors affecting the adverse outcome of neonatal seizures.
This is a prospective study conducted in the neonatal unit of a tertiary care hospital. One hundred and eight newborns consecutively admitted with seizures were included in this study.
Data was collected regarding perinatal history and seizure and evaluated for etiology. We conducted a retrospective analysis to identify the factors associated with adverse outcome after neonatal seizures.
Chi-square test with degree of freedom = 1 was used to find the variables significantly associated with adverse outcome (P < 0.05).
Gestational age, birth weight, Apgar score at 5 min, seizure onset <24 hrs, status epilepticus, radiological findings and EEG findings were significantly associated with outcome.
Mortality and severe neurological impairment after neonatal seizure is associated with prematurity, LBW, low Apgar score at 5 min, etiologies like meningitis, sepsis, severe HIE, brain malformations, grade 3 or 4 IVH or intracranial haemorrhage, seizure onset <24 hours, presence of status epilepticus, severely abnormal radiological and EEG findings.
早期发现不良结局的预测因素将有助于新生儿科医生提前规划管理、随访和康复,从而将神经功能障碍降至最低。
本研究的目的是确定影响新生儿惊厥不良结局的因素。
这是一项在三级护理医院新生儿病房进行的前瞻性研究。本研究纳入了108例连续入院的惊厥新生儿。
收集围产期病史和惊厥相关数据,并对病因进行评估。我们进行了一项回顾性分析,以确定新生儿惊厥后与不良结局相关的因素。
采用自由度为1的卡方检验来找出与不良结局显著相关的变量(P < 0.05)。
胎龄、出生体重、5分钟时的阿氏评分、惊厥发作<24小时、癫痫持续状态、影像学检查结果和脑电图检查结果与结局显著相关。
新生儿惊厥后的死亡率和严重神经功能损害与早产、低出生体重、5分钟时阿氏评分低、脑膜炎、败血症、重度缺氧缺血性脑病、脑畸形、3级或4级脑室内出血或颅内出血等病因、惊厥发作<24小时、癫痫持续状态的存在、严重异常的影像学和脑电图检查结果有关。