Bakker Erik N T P, Groma Gergely, Spijkers Léon J A, de Vos Judith, van Weert Angela, van Veen Henk, Everts Vincent, Arribas Silvia M, VanBavel Ed
Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, the Netherlands.
Department of Vascular Medicine and Nephrology, Academic Medical Center, Amsterdam, the Netherlands.
PLoS One. 2014 Sep 24;9(9):e107998. doi: 10.1371/journal.pone.0107998. eCollection 2014.
Spontaneously hypertensive rats (SHR) have been used frequently as a model for human essential hypertension. However, both the SHR and its normotensive control, the Wistar Kyoto rat (WKY), consist of genetically different sublines. We tested the hypothesis that the pathophysiology of vascular remodeling in hypertension differs among rat sublines.
We studied mesenteric resistance arteries of WKY and SHR from three different sources, at 6 weeks and 5 months of age. Sublines of WKY and SHR showed differences in blood pressure, body weight, vascular remodeling, endothelial function, and vessel ultrastructure. Common features in small mesenteric arteries from SHR were an increase in wall thickness, wall-to-lumen ratio, and internal elastic lamina thickness.
Endothelial dysfunction, vascular stiffening, and inward remodeling of small mesenteric arteries are not common features of hypertension, but are subline-dependent. Differences in genetic background associate with different types of vascular remodeling in hypertensive rats.
自发性高血压大鼠（SHR）常被用作人类原发性高血压的模型。然而，SHR及其血压正常的对照品系Wistar Kyoto大鼠（WKY）均由基因不同的亚系组成。我们检验了高血压血管重塑的病理生理学在大鼠亚系间存在差异这一假设。
我们研究了来自三个不同来源的6周龄和5月龄WKY和SHR的肠系膜阻力动脉。WKY和SHR的亚系在血压、体重、血管重塑、内皮功能和血管超微结构方面存在差异。SHR的小肠系膜动脉的共同特征是壁厚度、壁腔比和内弹性膜厚度增加。
小肠系膜动脉的内皮功能障碍、血管硬化和内向重塑并非高血压的共同特征，而是依赖于亚系。遗传背景的差异与高血压大鼠不同类型的血管重塑相关。
